Melania Trump was booed while delivering remarks at a youth opioid awareness event in Baltimore on Tuesday.

Jeers from some members of the audience could be heard as Trump wrapped up a brief speech at the B’More Youth Summit.

Trump was “greeted with some cheers but also a resounding chorus of loud boos, which lasted for about one minute” from the crowd of more than 1,000 middle and high schoolers, according to a press pool report.

Trump has made battling opioid abuse one of the key pillars of her wide-ranging “Be Best” children’s wellness initiative that she launched last year. She’s traveled across the country and visited hospitals and community centers to discuss the nationwide epidemic.

“I hope that the knowledge you gain here will help you tackle the tough decisions you may be faced with, so that you can lead a healthy and drug-free life,” Trump told attendees at Tuesday’s summit.

“Get involved and be a part of the solution,” Trump urged the audience. “Talk to your family and friends about what you have learned and help them understand how they too can be part of this powerful movement.”

“I cannot recall another event where she was more negatively received. I believe it is also the first loud booing by an audience at a solo event with Mrs. Trump,” remarked CNN’s Kate Bennett, a pool reporter who noted her extensive history of covering Melania Trump events.

Trump’s appearance at the opioid event in Baltimore comes months after her husband made disparaging comments about the Maryland city.

While feuding in July with the late Rep. Elijah Cummings, who represented the area before his death last month, President Trump tweeted that Baltimore was a “disgusting, rat and rodent infested mess.”

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